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[38], which is equivalent to 510 LA g/day in humans, increases oxidative damage in aged rats

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however, residual confounding by baseline BMI, glycemic status, indication, and discontinuation timing remains difficult to exclude (137)

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Because GHK-Cu operates through cumulative signaling rather than peak concentration, researchers commonly build in an escalation: a lower dose in the first half of a cycle, a higher dose in the second half, followed by a deliberate rest period before starting again

Halford, S