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& Tsujisaka Y., 1964

The results showed that 11 patients experienced mild nausea (n=6) and vomiting (n=5), with no serious adverse reactions or deaths

Amyloid aggregates form when the membrane-bound amyloid precursor protein (APP) undergoes a series of proteolytic cleavages orchestrated by -secretase (beta-site APP-cleaving enzyme, BACE) and furthered by -secretase [50]

However, some can interact with medications or have side effects at very high doses

The evidence that exists is indirect, drawn from switching studies, pharmacological principles, and real-world clinical observations

248 ZhaiQ.XiaoY.LiP.TianF.ZhaoJ.ZhangH.et al (2019)