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Retrieved February 11, 2026 from Ellis E

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I also observed a worsening of pre-existing POTS symptoms a condition that, in hypermobile Ehlers-Danlos Syndrome, is not incidental but mechanistically downstream: a recognized consequence of defective extracellular matrix that can produce peripheral venous laxity, impaired lower-extremity vasoconstriction, chronic hypovolemia, and the compensatory hyperadrenergic state that characterizes the neuropathic POTS phenotype

Treatment requires close monitoring because the medicine carries significant risks, especially for patients who can become pregnant

Placebo was provided as normal saline, the volume matching the investigational drug at each dose level