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Pharmacokinetics (Coskun et al., Cell Metabolism 2022) Phase 1 PK data established the ~6-day half-life and once-weekly dosing rationale

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A large study by Ohno and colleagues, published in Nature in 2020, found that the risk of developing RA rises with every roughly 5 kg of weight gain or every inch added to your waistline

Source: Phentermine label and Vyvanse label Phentermine and Vyvanse drug interactions The most serious Vyvanse drug interaction occurs when Vyvanse is taken with monoamine oxidase inhibitors (MAOIs)