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however, the combo group showed a significant decrease ( p = 0.001)

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These forward and reverse TCA cycle fluxes are not necessarily exclusive, which is frequently seen in cancer (Mcguirk et al, 2013), and although the direction of these fluxes are determined by the ratio of KG to citrate (Fendt et al, 2013), the upstream determinants of this ratio are yet to be fully described

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The potential reasons for the superior performance of RF and ET are as follows: Firstly, RF and ET excelled at capturing complex non-linear relationships and variable interactions, making them highly effective in medical prediction tasks

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