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It's worth noting that this gastric emptying delay may attenuate over time with chronic use (tachyphylaxis), though clinically relevant effects often persist

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This review article will introduce some of the small molecule drugs that are currently receiving significant attention: Orforglipron Orforglipron is an oral small molecule GLP-1RA developed jointly by Eli Lilly and Chia Tai Tianqing Pharmaceutical Group