High levels of UA inhibit the growth of the pancreatic -cell lines (INS-1 and RIN-m5F) in a time- and dose-dependent manner via the ROS-AMPK-ERK signaling pathway [31]
4.1.2 Treatment approaches post-chemotherapy New approaches to delivering chemotherapy agents can bring forth many new concepts, such as delivering agents capable of mediating the TME, including growth factors, which not only better the efficacy of chemotherapy but also provide these additional benefits
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