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186 On the other hand, in a randomized controlled trial in 260 men with abnormal sperm number, motility, and morphology, 60 mg of saffron daily for 26 weeks resulted in no differences relative to placebo with regard to sperm density, motility, or morphology, or semen antioxidant capacity

The initial study, by Alberti et al

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Control cells were treated with H 2 O 2 (1 mM) for 30 min as a positive control for increased ROS production

de Aquino Lemos V, Dos Santos RVT, Antunes HKM et al (2018) Melatonin and sleep responses to Normobaric hypoxia and aerobic physical exercise: A randomized controlled trial