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Mechanism-based research considerations include: Altered methylation: NNMT inhibition affects SAM, a participant in many methylation reactions

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At week 40, mean dose of insulin glargine was 38, 36, 29, and 59 units/day for patients receiving MOUNJARO 5 mg, 10 mg, 15 mg, and placebo, respectively

Weight-based dosing considerations While the standard clinical trial protocols use fixed-dose titration schedules regardless of body weight, some researchers adjust their approach based on body composition

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