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This ATP maintenance, coupled with sustained foraging activity (Supplementary Fig

In one of the Stephens Groups studies they found that a 15% increase in skeletal muscle carnitine content resulted in a 30% decrease in muscle PDC activity and a 40% decrease in muscle lactate content, leading them to conclude These results suggest that an acute increase in human skeletal muscle total carnitine content results in an inhibition of carbohydrate oxidation in conditions of high carbohydrate availability, due to a carnitine-mediated increase in fat oxidation. As an explanation Philip Randle in the 1960s undertook a series of landmark and controversial studies detailing the workings of the balance between fatty acid oxidation and glucose oxidation in what he called the glucosefatty acid cycle (Randle et al

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