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Frozen-then-thawed FMT units prepared from the single donor were instilled by enema and retained for 30 m in patients with HE after a 5-day course of broad spectrum antibiotics (metronidazole, ciprofloxacin, and amoxicillin) aimed to decrease host bacterial burden and make the colonic environment more receptive to colonization from the donor microbiota

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Originally used for Type 2 diabetes, these medications are being repurposed for a wider range of health conditions, prompting an evolution in chronic disease treatment paradigms

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Researchers might consider how this combination could lead to more robust or sustained metabolic improvements compared to using either peptide alone