In this study, we revealed that the crosstalk between androgen and Wnt/-catenin signaling plays a major role in the increase in wool and active hair-follicle density due to the activation of c-MYC and KRTs associated with inner root sheath (IRS) in FGF5 KO sheep, and the Shh pathway is also involved in this process as a downstream pathway of Wnt/-catenin signaling
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In hepatocytes, LSD1 is recruited by SHP as part of the FGF19SHPLSD1 axis to the Tfeb promoter
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Large-scale genomic sequencing efforts, such as The Cancer Genome Atlas (TCGA), have provided unprecedented insight into the molecular pathogenesis of HNSCC, confirming frequent somatic alterations in key signaling pathways [12]
