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Key selection factors highlighted in this comparison include MOQ flexibility, cost-efficiency at scale, supplier reputation (review scores, years in business), formulation complexity (combination actives), and regional manufacturing strengths

DOI: 10.1126/science.1093123 Rutigliano G et al (2028): The Case for TAAR1 as a Modulator of Central Nervous System Function

In certain embodiments, any controlled-release otic formulation described herein increases the exposure of an active agent and increases the length of time that the concentration of the active agent is above C min by about 30%, about 40%, about 50%, about 60%, about 70%, about 80%, or about 90% compared to a formulation that is not a controlled-release otic formulation

The capacity of Cas9 mRNA and FGF5 sgRNA for native gene disruption activity at its target locus was determined by DNA sequencing in microinjected individuals

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