Enzymatic degradation by proteases and chemical instability can limit therapeutic effectiveness and require specialized storage and handling procedures
For the cumulative incidence and hospitalizations analyses, the study focuses on individuals with more than 80 percent adherence, allowing us to assess the outcomes of near continuous therapy
It is not approved for clinical use as sold
Moreover, fingerstick testing provides a snapshot of glucose levels at a specific moment, rather than a continuous stream of data, potentially missing out on critical fluctuations
Jastreboff et al., NEJM 2022 (SURMOUNT-1)
If hair loss develops while on tirzepatide, it is crucial to determine whether it is telogen effluvium (non-scarring, diffuse, reversible) or lupus-related alopecia (which may be scarring and requires different management)