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At 5mg/mL, doses above 5mg exceed the syringe
This pattern appears consistently across obesity medications and likely reflects the metabolic differences that accompany established diabetes
Researchers are now studying whether therapies can produce: Greater fat loss Better preservation of skeletal muscle Improved muscle quality Stable or improved strength Better physical function Reduced visceral and ectopic fat Improved cardiometabolic health A 2026 phase 2 trial, for example, tested the investigational myostatin-pathway drug apitegromab alongside tirzepatide and found greater short-term lean-mass preservation than tirzepatide alone
These are the same mechanisms that make injectable GLP-1 medications effective for weight loss, just delivered through a pill instead of a needle
Adults (18 years) with overweight or obesity BMI 30 kg/m2 *OR* BMI 27 kg/m2 with 1 weight-related comorbidity (hypertension, dyslipidemia, obstructive sleep apnea, cardiovascular disease) This trial was for patients without type 2 diabetes Objective of the 2 year trial: To compare the 2-year effect of semaglutide 2.4 mg once weekly, vs placebo, on body weight, cardiovascular risk factors, and glucose metabolism
Neither medication is inherently "better" - the right choice depends on your health history, risk profile, medication tolerance, and your provider's clinical assessment
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