Clinical studies have confirmed that hyperhomocysteinemia is not only an independent risk factor for the development of cardiovascular and cerebrovascular diseases, such as atherosclerosis, acute myocardial infarction, stroke, coronary artery lesions, and peripheral vascular disease, but also increases the risk of neurodegenerative disorders and tumors, and impairs the efficacy of antifolate drugs
Mechanistically, it makes sense: glutathione is central to toxin clearance, mitochondrial protection, and antioxidant defense, and the nasal route offers a practical way to bypass digestive breakdown and possibly reach brain and respiratory tissues more directly
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In other words, this method is based on the ability of antioxidants to reduce the ferric 2,4,6-tripyridyl-s-triazine complex [Fe 3 -(TPTZ)] 3 to the intensely blue-colored ferrous complex [Fe 2 -(TPTZ)] 2 in an acidic medium