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Cardiovasc Drugs Ther (2013) 27:37180

doi: 10.1016/j.cell.2022.02.011

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[86] Phosphodiesterase inhibitors (PDE) [edit] A 2018 Cochrane review of studies on men over 60 with moderate to severe lower urinary tract symptoms analyzed the impacts of phosphodiesterase inhibitors (PDE) in comparison to other drugs

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This modulation was paralleled by improved mucosal morphology, increased expression of tight junction proteins (occludin, claudin-1, ZO-1), and reduced colonic inflammation