In addition to being polypharmacologically beneficial, this method would appeal to organisations funding healthcare in the licensing of AOMs
10.1021/acschembio.9b00939 257 YinJ.LinY.FangW.ZhangX.WeiJ.HuG.et al (2022)
Results clearly showed that the tyrosine-nitration level was reduced in proportion to the molar ratios of GSSSG and LASSS relative to HGF, as revealed by the decrease in anti-nitroY mAb-positive HGF (60-kDa -chain and 90-kDa proform) normalized to total HGF -chain as a loading control, that was monitored by stripping with SDS-ME solution and re-probing the blot with anti-HGF -chain N-terminal domain mAb (Figure 1b,c, second and third rows)
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The role of NCOA4 in ferroptosis was determined by silencing the expression of NCOA4 by siRNA lentiviral transfection, and the result shows that an iron chelator-like effect was produced in the NCOA4-deficient KGN after ferric citrate (FAC) intervention (Fig
