There is no known cure for neuropathy, so management focuses on preserving foot integrity and quality of life using pharmacologic agents (e.g., duloxetine, pregabalin) for symptomatic relief and ensuring protective footwear or podiatry interventions where available
This slow titration helps your body adjust and minimises side effects: 6 Weeks 1-4: 0.25 mg once weekly Weeks 5-8: 0.5 mg once weekly Weeks 9-12: 1.0 mg once weekly Weeks 13-16: 1.7 mg once weekly Week 17 onwards: 2.4 mg once weekly (maintenance dose) Practical tips for taking both medications Inject Wegovy on the same day each week, at any time of day, with or without food Continue taking metformin with meals as prescribed Stay well hydrated, especially if experiencing gastrointestinal side effects Eat smaller, more frequent meals if nausea is troublesome Limit ultra-processed food and take-aways Who should not combine Wegovy and metformin
Retatrutide , a triple agonist targeting GLP-1, GIP, and glucagon receptors simultaneously, is advancing through clinical trials and may offer even more pronounced anti-inflammatory and metabolic effects than current options
Not thought to be diet related Thought to be diet related Cyanocobalamin tablets 50150 micrograms daily between meals(see self-care section below) or Twice-yearly hydroxocobalamin 1 mg injections
In mammals, sulforaphane can similarly upregulate stress-induced signaling pathways, including the Nuclear Factor Erythroid 2-related Factor 2 (NRF2) transcriptional pathway, which is conserved across mammalian species, but absent from plants (Gacesa et al., 2016
You may also feel more nauseated when stool backs up