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Moisture-wicking sheets made from bamboo or special performance fabrics pull sweat away from the body Cooling mattress pads with gel layers or water circulation systems regulate temperature throughout the night Breathable sleepwear designed for hot flashes keeps skin dry Cooling pillows with ventilated designs prevent head and neck overheating A consistent bedtime routine signals the body to prepare for sleep

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Methods Construct modification and expression of full-length GLP-1R The optimized gene of full-length GLP-1R was cloned into the modified pFastbac1 vector at the BamHI/HindIII sites and the native signal sequence was replaced by haemagglutinin (HA) to enhance receptor expression (see primers in Supplementary Table 2), followed by a flag-tag, a 10 His-tag and a tobacco etch virus protease (TEV) site at the N-terminus

The harvested skin samples were frozen and sectioned into 4-m slices, mounted onto glass slides, and examined using a fluorescence microscope (DMi8, Leica, Germany)