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Linagliptin significantly increased LS-mean insulin response to OGTT by 55% (95% CI 39.05, 71.74%) in the high GLP-1 compared to 12% (95% CI -4.05, 29.01%) in low GLP-1 group, resulted in a significant between-group difference (p = 0.002) ( Figure 3F )

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Statistical analysis For all studies, Students t -test or Wilcoxon rank sum test was performed to compare the differences between two groups

0.25 mg or 0.5 mg dose 1 mg dose 2 mg dose There are potential significant safety risks associated with taking compounded "semaglutide"