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Grgic, T., Banic, T., & Sikiric, P

It actually exists in human plasma - the problem is, it declines with age

The evidence that exists is largely in vitro (dermal papilla cells) and ex vivo (isolated follicles), plus mechanistic and gene-expression data and patents

These findings may help explain historical interest in pain and withdrawal research, but they do not establish an opioid-like clinical effect in people