In this way, the researchers demonstrated that cerebral disease in argininosuccinic aciduria involves neuronal oxidative and nitrosative stress independent of hyperammonaemia (a disease that gives rise to elevated ammonia levels in the blood)
Folic acid attenuates homocysteine and enhances antioxidative capacity in atherosclerotic rats
Acta Pharmacol Sin 2000
While KYN itself is not neuroactive, it is a branching point for two major metabolic routes: one leading to the synthesis of kynurenic acid (KYNA), which occurs in astrocytes, and another leading to the synthesis of picolinic acid (PA) and quinolinic acid (QA), occurring in microglia, with QA serving as a precursor for nicotinamide adenine dinucleotide (NAD) [25, 26]
Though it is naturally produced in the body, ageing, poor diet, environmental pollutants, and stress can lower its levels, resulting in increased oxidative stress and hyperpigmentation
Evans EPP, Scholten JTM, Mzyk A, et al