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p53-pS15 combined with FOXO4 in the nucleus of senescent cells inhibits p53 into the cytoplasm to mediate apoptosis and halt the cell cycle 9,11

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RCT conducted in patients with T2D showed that high doses of tirzepatide represent the most efficacious incretin-based anti-diabetes drug in terms of BW reduction 33 , sustaining the development of the SURMOUNT program to explore its efficacy and safety in the management of obesity 9