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MOTS-c is typically administered via subcutaneous injection into the abdomen, lateral thigh, or flank, rotating injection sites to prevent tissue accumulation

This approach means starting at a lower dose and increasing it gradually based on your body's response, which may help significantly reduce side effects

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Topical gene silencing by iontophoretic delivery of an antisense oligonucleotide-dendrimer nanocomplex: the proof of concept in a skin cancer mouse model

When outcomes were reported at multiple time points, the most recent follow-up data were extracted to maintain consistency across studies

All animal experiments were conducted in accordance with ARRIVE guidelines to ensure ethical and transparent reporting of in vivo research 28