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Conversely, DKD in type 2 diabetes mellitus shows greater pathological heterogeneity, with some people developing classical glomerular lesions, while others present with atypical features such as prominent tubulointerstitial damage, vascular abnormalities, or coexisting non-DKD pathology [21,22]

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The accumulation of AGEs in patients with CKD is a result of oxidative stress and inflammation and can come from external sources such as diet and smoking (93, 94)

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Receptor Pharmacology GLP-1 and GIP are hormones secreted by the intestine in response to nutrients