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Steady weight change : One to two pounds per week, or measurable changes in waist circumference

PMID 33831374

Patient safety must take precedence over concerns about waste or inconvenience

The therapeutic utility of native GLP-1 is limited by its rapid degradation [2], primarily mediated by dipeptidyl peptidase-4 (DPP-4) and secondarily by neutral endopeptidases (NEPs) and renal clearance [3, 4]

This is the worst the GLP drugs will ever be The smartest person I know in medicine, Dave Park, has told me the only reason surgeons ever have something to do is because medicine hasnt figured out how to solve the problem yet. And in that spirit, todays newsletter is about celebrating the advances in the field of the GLP drugs, which are solving a problem I didnt think medicine would ever solve: curing obesity and metabolic syndrome in our modern food and movement environment

Set realistic goals: Help patients set achievable weight loss and fitness goals that they can maintain in the long run