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The relationship between GLP-1As and alopecia is not fully understood and is likely multifactorial, including rapid weight loss (triggering telogen effluvium), hormonal and insulin-like growth factor-1 changes may trigger early onset of AGA, androgen fluctuations, and nutritional deficiencies

One further nuance worth noting: the addition of GIP in both tirzepatide and retatrutide is hypothesised to improve gastrointestinal tolerability relative to GLP-1 alone at comparable efficacy

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Its safety profile is the most thoroughly documented of the GHRH family

And essentially there's an idea there was a paper relatively recently, I think, that was finally studying this concept that people have been kind of floating around that if you stop them you'll end up in a worse state than actually where you started

10.1016/j.phrs.2022.106306 126 LiK.LinC.LiM.XuK.HeY.MaoY.et al (2022)