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Managing Side Effects During Dose Transitions Nausea, constipation, and loss of appetite are expected during the first few days after a dose increase

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At the 0.25 mg starting dose, even a 2 mg vial lasts 8 weeks, but you can only safely use it for 4 weeks

In a 104-week extension (BMI 35 subgroup), mean weight loss reached -30.3% at 12 mg meaning the curve was still descending well past 80 weeks

While both can affect hormone levels and performance, they differ significantly in structure, mechanism and regulation

Dietary modifications support tolerance: increase soluble fiber gradually, stay well hydrated (at least 23 liters daily), limit high-fat foods that accelerate transit, and eat smaller, more frequent meals