64 A 90-day administration of dexamethasone (DEX) resulted in significant declines in both BMD and BMC, along with substantial increases in serum levels of glucose, insulin, triglycerides, total cholesterol, parathyroid hormone (PTH), osteoprotegerin (OPG), and bone resorption markers including deoxypyridinoline (DPD), N-terminal telopeptide of type I collagen (NTX-1), and TRAP-5b
Therefore, its bioavailability is estimated at around 0.4% to 1%
One thing to keep in mind: fat triggers a slower GLP-1 response compared to protein or fiber
Another possible candidate neuron population for the GLP1 receptor induced regulation of eating within the paraventricular hypothalamic nucleus are CRH neurons
Why the warning lands now The advisory arrives as Canadian demand for GLP-1 products remains high
Gastric emptying slows by 30-40%