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Improved metabolic flexibility Obesity and type 2 diabetes are commonly associated with impaired metabolic flexibility, meaning the body has difficulty switching efficiently between glucose and fat oxidation

Further characterization using doseresponse assays revealed reliable dose-dependent effects from all the primary hits (Fig

doi: 10.1093/ndt/gfv459 202 MullerLMGorterKJHakEGoudzwaardWLSchellevisFGHoepelmanAIet al

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10.1002/hipo.20665 Hippocampus

Furthermore, the occurrence of an oxidized form of -glutamylcysteine in all tissues analysed, in vivo , strongly suggests the notion of a -glutamylcysteine redox cycle