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In summary, these histopathological results indicated that the homozygous N1437D mutation of LRRK2 did not affect the terminal density of TH in the striatum at 2627 months of age but reduced the numbers of dopaminergic neurons in the SN and the level of DAT in the system

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Kobilka, M.P

(2) Interference with mitochondrial fusion protein function: Oligomeric -syn binds to the lipid components of the outer mitochondrial membrane (OMM), thereby reducing the rate of mitochondrial fusion and resulting in mitochondrial fragmentation (Panicker et al., 2021

These included 2 events of tonsillar hypertrophy

Both substances influence dopamine release and reward signaling, but they act through different pathways