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and (6) Priming and Repriming establishing the actuations needed before consistent dosing is achieved

For chronic injuries or conditions, patients may require ongoing treatment to maintain optimal benefits

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In a cellular model of dopamine neurotoxicity induced by fisetinone, silencing of PGC-1 expression was found to significantly increase the protein expression levels of PINK1, parkin, and their phosphorylated proteins (Peng et al., 2019)