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The discrepancy between NADPH synthesis and consumption determines the intracellular NADPH level

The Nrf2 pathway is a negative regulator of inflammation according to the hierarchical oxidative stress model [8, 9]

Alkaline phosphatase knock-out mice recapitulate the metabolic and skeletal defects of infantile hypophosphatasia

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Sulforaphane protects human umbilical vein cells against lipotoxicity by stimulating autophagy via an AMPK-mediated pathway

[5] Some of those affected also have irritable bowel syndrome and fibromyalgia