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Abstract To determine whether combination therapy (semaglutide + metformin) is more efficacious than monotherapy (metformin alone) in reducing the risk of antipsychotic-induced weight gain (AIWG) in patients with Type 2 Diabetes Mellitus (T2DM)

semaglutide offers a meaningful step up in efficacy with weekly dosing

Early studies suggest it may provide more potent metabolic signaling than single or dual agonists, supporting appetite regulation, insulin sensitivity, and energy expenditure

10.1161/JAHA.115.002767 136 SeshadriS.BeiserA.SelhubJ.JacquesP

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