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Moreover, some environmental and lifestyle factors, such as poor nutrition, stress, alcohol consumption, smoking, and continuous exposure to UV radiation and pollution, also reduce glutathione reserves in our bodies

Increased arterial stiffness in cerebral conduit arteries impairs their ability to dampen blood flow ejected from the heart, leading to transmission of high pressure and pulsatile blood flow to the cerebral microvasculature and neuronal tissue

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They dynamically regulate genome accessibility by globally rewriting epigenetic codes, such as histone modifications and DNA methylation, and remodeling the three-dimensional chromatin architecture