To test if MOTS-c can improve physical performance in mice that have been on a HFD, we fed young C57BL/6J mice a HFD, or a normal diet, for 2 weeks before initiating daily MOTS-c injections (15 mg/kg/day) for 2 weeks prior to a treadmill running test (Supplementary Fig
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221,222 Likewise, inhibiting mTOR, particularly with the drug rapamycin, extends lifespan and delays the onset of age-related illnesses in several species
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Gastrointestinal Health: Given its origin in the gastric system, BPC-157 has been studied for its potential to protect the gut lining, reduce inflammation, and support the healing of ulcers
The dosing protocols differ significantly between the two medications, with tirzepatide starting at 2.5 mg weekly and potentially escalating to 15 mg based on tolerance and response