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For patient treatment, approved GLP-1 or GIP/GLP-1 medications remain the practical comparison point until regulators decide whether to approve cagrilintide-containing products

PMCID: PMC10242177

Originally developed as a prescription therapy for fat redistribution in HIV patients, this powerful growth hormonereleasing hormone (GHRH) analog is now used off-label by athletes and wellness enthusiasts to boost IGF-1, reduce visceral fat, and support lean muscle retention

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Anyone considering retatrutide whether through a clinical trial or any other route should consult their GP or a specialist before proceeding, particularly if they are already taking testosterone or any other hormonal therapy

Semaglutide is not recommended for individuals with certain medical conditions conditions such as a history of pancreatitis, a personal or family history of medullary thyroid cancer or current kidney disease