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Because tirzepatide activates a broader receptor footprint, it is studied as a model for combinatorial incretin pharmacology rather than single-pathway agonism

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This compound, known as exenatide, mimics the effects of GLP-1, a hormone that plays a critical role in appetite suppression, insulin secretion and glucose metabolism

Preclinical studies in rats and non-human primates using c-Fos immunoreactivity mapped receptor-linked hypothalamic activation

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4F) and reduction in daily food intake in PNA mice treated with metformin (Fig