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These reactive oxygen species, generated by UV radiation, pollution, and normal metabolic processes, are major contributors to premature skin aging

Based on the outcome of the BLOOM (46) and BLOSSOM trials (47), in 2012 the FDA approved lorcaserin as an addition to a reduced-calorie diet and exercise for eligible patients (48)

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In this study, TEM revealed mitochondrial swelling and autophagosome accumulation in scattered lymphocytes and ductal cells of the LSGs of patients with pSS, which is an important finding