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Lewallen CG, Rall JE, Berman M

It has been demonstrated that increasing ROS could easily result in dysfunctions of proliferation or differentiation in AML, and could be an effective strategy for overcoming drug resistance in leukemia [21]

Reduced L-Glutathione is the glutathione form commonly abbreviated to GSH

GPX4 catalyzes the substrate, and the product consumes the reducing agent with the addition of enzyme reagents.The reducing agent has a maximum absorbance at 340 nm, and the GP4-specific enzyme activity can be calculated by measuring non-specific enzyme activity and total enzyme activity by adding GPX-4 inhibitor to the system

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