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The synthesis of mitochondrial membrane, mtDNA replication, transcription, translation, and the synthesis and import of mitochondrial proteins encoded by nuclear DNA are important factors in the process of mitochondrial biogenesis (Golpich et al., 2017

When 5-Amino-1MQ inhibits NNMT, nicotinamide is preserved and available for NAD+ synthesis, leading to increased intracellular NAD+ concentrations

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