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The vast majority of the excitatory neurons in your nervous systemincluding your brain and spinal cordare glutamatergic, which means they are activated by glutamate

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The core concept remains the same for both forms: a peptide that stimulates the pituitary gland through the GHRH receptor

While earlier GHRPs activate multiple endocrine pathways causing spikes in cortisol, ACTH, prolactin, and appetite alongside GH ipamorelin produces a much cleaner GH-specific response

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