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Disrupted peripheral neurogenic signaling pathways between the liver and the brain axis, coupled with perturbed central neurotransmission within the brain, in tandem with disease-related or disease-associated factors, such as complications, treatments, and severity, as well as alcohol use, metabolic syndrome, and malignancy, collectively contribute toward clinical fatigue (10)

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TB-500 also upregulates the expression of VEGF to induce angiogenesis, having been proposed as a potential treatment of cardiac injury

190 Given the positive outcomes with L-carnitine and/or acetyl-L-carnitine, it has been included in combination with antioxidants and other nutrients

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These findings underscore the clinical relevance of SLC25A39 as a potential therapeutic target in CRC management