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Common indicators include: Struggling with traditional diet and exercise methods BMI over 30, or over 27 with weight-related health issues Difficulty controlling appetite or food cravings Weight-related health conditions like diabetes or high blood pressure Yo-yo dieting patterns Slow metabolism affecting weight loss efforts For some individuals, repeated attempts at losing weight without lasting results can be frustrating and discouraging

doi: 10.1172/jci.insight.140532 110 ZhaoFZhouQCongZHangKZouXZhangCet al

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Front Oncol (2022) 12:863107