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Several developments are worth watching

OTHERS Recent investigations have elucidated a multifaceted spectrum of adverse effects linked to GLP-1 RAs (Table 1), necessitating meticulous interpretation based on the various methodological designs employed, including RCTs and retrospective analyses

Why It Matters for Patients Stronger satiety signals: Patients feel full sooner and may find it easier to stick with smaller meals

Retatrutide activates three and reaches 28.7%

Patients should never discontinue GLP-1 medications without medical guidance, as abrupt cessation may lead to worsening glycemic control or weight regain

Given the independent replication of our observed directionality in an external cohort using EHR data, the directionality inferred by our study is unlikely to be the result of a data quality issue