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And people have gradually realized the importance of immune cells in TME in anti-tumor therapy with the discovery of immune checkpoints and their significant efficacy in anti-tumor therapy (3), the immune cells in TME mainly include tumor-associated macrophages (TAMs), natural killer (NK) cells, dendritic cells (DCs), tumor-associated neutrophils (TANs), myeloid-derived suppressor cells (MDSCs) and T cells (4)