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United States 10.8

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Participants with metabolic dysfunction-associated steatotic liver disease showed significant reductions in liver fat content with retatrutide treatment

Chronic exposure to elevated free fatty acids (FFAs) leads to -cell apoptosis and decreased insulin secretion, which contributes to the progression of T2DM (45)

For Likert-scale statements, consensus was set at a pre-defined threshold of 75% respondents selecting strongly agree/agree or strongly disagree/disagree

Pathway Convergence and Pleiotropic Effects Studies based on pathway classification indicate that many peptides can activate multiple signaling cascades simultaneously (Table 4)