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Under metabolic stress, MOTS-c translocates from cytoplasm to nucleus and regulates expression of nuclear genes in an AMPK-dependent manner (Kim et al., 2018, PMID 29983246)
Retatrutide (LY3437943) simultaneously activates GLP-1, GIP, and glucagon receptors, distinguishing it from approved dual or single agonists such as tirzepatide and semaglutide
Data analysed by two-way repeated measures ANOVA to assess main effects of treatment ( a and b )
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