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Clin Ther 2011;33:93445.ArticlePubMed 18

These compounds could be possible agents for treating hyperuricemia and gout [75]

The single pgdS gene knockout, as well as the double knockout of pgdS and ggt gene, resulted in a drastic reduction in PGA production, while the single ggt gene knockout improved PGA production due to lesser degradation (Ojima et al., 2019)

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Deletion of this gene in mice leads to the decrease in synaptic coverage by astrocytic leaflets, which translates into reduced densities of glutamatergic synapses